Development of Stereotactic Ablative Radiotherapy: Radiotherapy Experience, Clinical Applications of the Stereotactic Method and Widespread Development of Stereotactic Apparatus and Techniques
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Radiotherapy Experience, Clinical Applications, Development of Stereotactic, Apparatus, TechniquesAbstract
Over the past half-century, stereotactic radiosurgery (SRS) has shown to be a successful method for treating both benign and malignant brain diseases. Stereotactic ablative radiotherapy (SAbR) in extracranial sites is currently challenging conventional wisdom in radiation oncology, much like SRS revolutionised neurosurgery. After William Coolidge created the high vacuum X-ray tube in 1913, "therapeutic radiology" took a giant leap forward. Therapy of deeper seated tumours would be possible within 10 years and for numerous decades to come with tube potentials exceeding 200 kV. It was well-known in the early days of radiation that low intensity X-rays couldn't penetrate very far. In response, several systems were developed to enable multi-beam delivery. Dosimetric compactness attained by aiming with numerous intersecting, non-overlapping beams is a basic idea in radiosurgery. These approaches lay the groundwork for this principle without using stereotactic localisation. Hence, ionising radiation's oncologic uses had little success during the first 30 years of the 1900s. Back then, we didn't know much about how time, dose, and radiation rate—three fundamental radiological parameters—impacted cell and tissue responses.
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