The Relationship between the Fourth Exon 8 Polymorphism of the CYP19 Gene and Estrogen in Local Awassi Ewes

Razzaq Nasser Abed

Authors

Razzaq Nasser Abed Department of Medical Biotechnology, College of Biotechnology – Al-Qasim Green University, Iraq

Keywords:

Exon8, CYP19 Gene, Local Awassi ewes, Hormone estrogen

Abstract

The objective of this study was to examine the effect of exon 8 CYP19 gene polymorphisms on Local Awassi ewes’ oestrogen level. The highest level of the hormone was 16.33 pg/ml and the lowest level of the hormone was 9.38 pg/ml. When exon 8 of CYP19 gene was observed to be 105 base pairs the genotypes were also established. Distribution of CYP19 genotypes in local Awassi ewes were TT, TC and CC 20%, 30% and 50%, respectively. The results of this study showed that the TT and TC genotypes ( 15.57, 15.46) were significantly higher than CC (14.23) ( P < 0.05 ), but there was no significant different between TT and TC group. In the present study, TC genotype had a higher susceptibility compare to TT and CC genotypes of the polymorphisms in the exon 8 of CYP19 gene.

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