Gel With Proniosome- A Pioneering Approach For Drug Release
Keywords:
non- ionic, stabilizer, membrane, proniosomes, drug carrier.Abstract
Vesicular systems, such as liposomes and niosomes, offer distinct advantages over conventional dosage forms due to their role as reservoirs for drug encapsulation. These systems can function both as carriers and as permeation enhancers, facilitating drugpenetration through the skin's stratum corneum. Additionally, they serve as controlled percutaneous drug delivery vehicles, capable of modifying particle composition or surface characteristics for targeted drug delivery.However, the potential of these vesicular systems is limited by challenges like stability issues, sedimentation, aggregation, fusion, and drug hydrolysis, all of which affect the shelf life of the dispersion. To address these concerns, proniosomes were developed. Proniosomes consist of dry formulations of water-soluble carrier particles coated with nonionic surfactant
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