Estimate correlation between Aspergillus Spp. and Asthma Patients
Keywords:
Aspergillus Spp, Asthma PatientsAbstract
Fungal exposure is a daily fact of human existence that infrequently results in disease; Asthma is a chronic inflammatory disease of the airways characterized by respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and in intensity. The relationship between day-to-day changes in asthma severity and combined exposures to community air pollutants and aeroallergens remains to be clearly defined. There is a close association between fungi and asthma, the so-called fungal asthma. This study aimed to isolate the causative Aspergillus species that increase the risk of infection and to find out the association between asthma and Aspergillus spp. 40 sample of (sputum s and pharyngeal swabs) were collected from patients suffer from asthma symptoms. All samples were of both gender and of different age groups at the Specialized Center for Respiratory Diseases. Samples were grown on two culture media (SDA and MEA) and incubated at 37°C for 7 days. The numbers of positive samples were 32 on SDA medium, 29 on MEA medium. Isolates were identified using special culture media characteristics as well as macroscopic and microscopic analysis. Where A. flavus was found to be the most predominant species of the sputum (58%) and from the pharyngeal swab (58.82%) on SDA, while on MEA the most prominent species were A. flavus and A. terreus (35%) of the sputum and the pharyngeal swab was A.niger (42.11%). The Aspergillus genera showed resistance to Fluconazole, Amphotericin B and Nystatin. The study has concluded that, there is a correlation between asthma and Aspergillus species. Aspergillus flavus the most common Aspergillus associated with lung diseases (Asthma).
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