Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: Morphologic, Histologic Features, Clinical and Prognostic Implications of Novel Discoveries

Authors

  • Zahraa Mohammed Hassan Hadi College of Applied Medical Sciences, Pathological Analysis Department, Karbala University
  • Fatima Fakher Hadi Ibrahim College of Applied Medical Sciences, Pathological Analysis Department, Karbala University
  • Zahraa Hashem Ibrahim Mustafa College of Applied Medical Sciences, Pathological Analysis Department, Karbala University
  • Ali Hadi Hassan Khalif College of Applied Medical Sciences, Pathological Analysis Department, Karbala University
  • Saif Muslim Mohsen Arjawi College of Applied Medical Sciences, Pathological Analysis Department, Karbala University

Keywords:

Chronic Lymphocytic Leukemia, Morphologic, Clinical and Prognostic Implications.

Abstract

Two prevalent low-grade, typically indolent B-cell
lymphoproliferative disorders are chronic lymphocytic leukaemia (CLL) and
small lymphocytic lymphoma (SLL), which are lymph node tumours. Both
SLL and CLL can develop from preexisting low-level monoclonal or
oligoclonal B-cell expansions; unlike other B-cell malignancies, they do not
exhibit the hallmark reciprocal chromosomal translocations. At now, CLL/SLL
offers the most promising model among haematopoietic tumours for the
application of prognostic and predictive indicators to influence treatment
decisions. Additionally, CLL/SLL exemplifies the integration of serum
biomarkers with tumour immunophenotyping (FC, IHC), genomic profiling
(FISH, etc.), and tumour histogenesis studies (Ig gene expression mutation
status, for example) as a case study. Similar to chronic lymphocytic leukaemia
(CML) and acute lymphoblastic leukaemia (ALL), chemotherapy-induced
disease (CRD) monitoring by FC is now standard practice in post-treatment
care

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Published

2024-10-14

How to Cite

Hassan Hadi, Z. M., Hadi Ibrahim, F. F., Ibrahim Mustafa, Z. H., Khalif, A. H. H., & Mohsen Arjawi, S. M. (2024). Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: Morphologic, Histologic Features, Clinical and Prognostic Implications of Novel Discoveries. Current Clinical and Medical Education, 2(10), 92–103. Retrieved from https://www.visionpublisher.info/index.php/ccme/article/view/191

Issue

Vol. 2 No. 10 (2024)

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Current Clinical and Medical Education