Nutritional Effects of Polyphenols, Dietary Fiber, Prebiotic effect, Compounds Associated with Dietary Fiber and Impact of Polyphenols on Human Intestinal Microbiota and Their Health Benefits

Authors

  • Hawraa Ridha Jubair, Farah Kazim Abbas Al-Qasim Green University, College of Food Sciences, Department of Food Science and Technology, Iraq
  • Baneen Hussein Ali, Haidar Muhammad Akool, Tabarek Mohsin Dhahir Al-Qasim Green University, College of Food Sciences, Department of Dairy Science and Technology, Iraq

Keywords:

Dietary Fiber, Polyphenols, Microbiota, Health Benefits

Abstract

As secondary metabolites found in plants, polyphenols have recently gained prominence as important bioactive chemicals that could have profound effects on human health.  Polyphenols found in plants can modulate many different physiological pathways through their direct or indirect interactions with biomolecules.  Polyphenols have attracted a lot of interest from researchers and doctors because of their structural variety and natural abundance.  Afterwards, learning where polyphenols come from in the diet helps shed light on the natural plant-based sources that make them available all over the world.  The intricate process from consumption to systemic effects is elucidated, and the conversation continues with the absorption and metabolism of polyphenols in the human body.  The review primarily aims to dissect polyphenols' antioxidant activities, drawing attention to their function in preventing oxidative stress and related health problems.  Their effects on a wide range of health issues, including hypertension, allergies, ageing, and chronic diseases (such as diabetes and heart attacks), are covered in detail in the analysis.  New information about polyphenols' positive effects on a worldwide scale highlights their promise as medicinal and preventative agents.  Depending on the phyto-antioxidant content, plant-based product consumption enhances human health and lowers the risk of developing and worsening numerous chronic diseases.  Ultimately, our extensive analysis has shed light on the significant health benefits linked to the intake of phyto-antioxidant-rich plant-based foods.  This eating style has shown a considerable decrease in the occurrence and worsening of various chronic diseases, supporting its promise as a foundation for improving human health.  Despite the fact that most people believe polyphenols' antioxidant properties are responsible for their health benefits, we must not forget that the exact mechanisms of action of certain phenolic compounds are complex and yet not fully known.  Addressing this information gap calls for a detailed investigation of polyphenol bioavailability in the hopes that this will lead to a better understanding of their health-promoting properties.  Our inquiry has broadened to include the several functions of polyphenols in illness management.  We have focused on their possible effects on metabolic syndrome, autoimmune diseases, respiratory health, pregnancy, and maternal health.  This detailed analysis of polyphenols in different pathophysiological settings improves our understanding of their multipurpose uses and highlights their promise as therapeutic approaches in several health paradigms.

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References

Arranz, S.; Silva’n, J.M.; Saura-Calixto, F. Nonextractable polyphenols, usually ignored, are the major part of dietary polyphenols: A study on the Spanish diet. Mol. Nutr. Food Res. 2010, 54, 1646–1658.

Pe’rez-Jime’nez, J.; Dı’az-Rubio, M.E.; Saura-Calixto, F. Non-extractable polyphenols, a major dietary antioxidant: Occurrence, metabolic fate and health effects. Nutr. Res. Rev. 2013, 26, 118–129.

Ding, Y.; Morozova, K.; Scamicchio, M.; Ferrentino, G. Non-extractable polyphenols from food by-products: Current knowledge on recovery, characterization, and potential applications. Processes 2020, 8, 925.

Jakobek, L.; Mati´c, P. Non-covalent dietary fiber-polyphenol interactions and their influence on polyphenol bioaccessibility. Trends Food Sci. Technol. 2019, 83, 235–247.

Fernandes, A.; Mateus, N.; de Freitas, V. Polyphenol-dietary fiber conjugates from fruits and vegetables: Nature and biological fate in a food and nutrition perspective. Foods 2023, 12, 1052.

Bié, J.; Spodes, B.; Fernandes, P.C.B.; Ribeiro, M.H.L. Polyphenols in health and disease: Gut microbiota, bioaccessibility, and bioavailability. Compounds 2023, 3, 40–72.

Ozdal, T.; Sela, D.A.; Xiao, J.; Boyacioglu, D.; Chen, F.; Capanoglu, E. The reciprocal interactions between polyphenols and gut microbiota and effects on bioaccessibility. Nutrients 2016, 8, 78.

Lorenzo, C.D.; Colombo, F.; Biella, S.; Stockley, C.; Restani, P. Polyphenols and human health: The role of bioavailability. Nutrients 2021, 13, 273.

Dieterich, W.; Schink, M.; Zopf, Y. Microbiota in the gastrointestinal tract. Med. Sci. 2018, 6, 116.

Bengmark, S. Ecological control of the gastrointestinal tract. The role of probiotic flora. Gut 1998, 42, 2–7.

Ley, R.E.; Turnbaugh, P.J.; Klein, S.; Gordon, J.I. Microbial ecology: Human gut microbassociated with obesity. Nature 2006, 444, 1022–1023.

Zhu, B.; Wang, X.; Li, L. Human gut microbiome–the second genome of human body. Protein Cell 2010, 1, 718–725.

Hugon, P.; Dufour, J.-C.; Colson, P.; Fournier, P.E.; Sallah, K.; Raoult, D. A comprehensive repertoire of prokaryotic species identified in human beings. Lancet Infect. Dis. 2015, 15, 1211–1219.

Thursby, E.; Juge, N. Introduction to the human gut microbiota. Biochem. J. 2017, 474, 1823–1836.

Hill, M.J. Intestinal flora and endogenous vitamin synthesis. Eur. J. Cancer Prev. 1997, 6, S43–S45.

Martens, J.H.; Barg, H.; Warren, M.; Jahn, D. Microbial production of vitamin B-12. Appl. Microbiol. Biotechnol. 2002, 58, 275–285.

Pompei, A.; Cordisco, L.; Amaretti, A.; Zanoni, S.; Matteuzzi, D.; Rossi, M. Folate production by bifidobacterial as a potential probiotic property. Appl. Environ. Microbiol. 2007, 73, 179–185.

Cho, I.; Blaser, M.J. The human microbiome: At the interface of health and disease. Nat. Rev. Genet. 2012, 13, 260–270.

Agostoni, C.; Kim, K.S. Nutrition and the microbiome. Pediatr. Res. 2015, 77, 113–114.

Conlon, M.A.; Bird, A.R. The impact of diet and lifestyle on gut microbiota and human health. Nutrients 2015, 7, 17–44.

Nettleton, J.E.; Reimer, R.A.; Shearer, J. Reshaping the gut microbiota: Impact of low calorie sweeteners and the link to insulin resistance? Physiol. Behav. 2016, 164 Pt B, 488–493.

Chassaing, B.; Koren, O.; Goodrich, J.; Poole, A.; Srinivasan, S.; Ley, R.E.; Gewirtz, A.T. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 2015, 519, 92–96.

Frame, L.A.; Costa, E.; Jackson, S.A. Current explorations of nutrition and the gut microbiome: A comprehensive evaluation of the review literature. Nutr. Rev. 2020, 78, 798–812.

David, L.A.; Mourice, C.F.; Carmody, R.N.; Gootenberg, D.B.; Button, J.E.; Wolfe, B.E.; Ling, A.V.; Devlin, A.S.; Varma, Y.; Fischbach, M.A.; et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014, 505, 559–563.

Moschen, A.; Wieser, V.; Tilg, H. Dietary factors: Major regulators of the gut’s microbiota. Gut Liver 2012, 6, 411–416.

Requena, T.; Martinez-Cuesta, M.C.; Pelaez, C. Diet and microbiota linked in health and disease. Food Funct. 2018, 9, 688–704.

Turnbaugh, P.J.; Ley, R.E.; Mahowald, M.A.; Magrini, V.; Mardis, E.R.; Gordon, J.I. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444, 1027–1031.

Zhang, H.; Di Baise, J.K.; Zuccolo, A.; Kudrna, D.; Braidotti, M.; Yu, Y.; Parameswaran, P.; Crowell, M.D.; Wing, R.; Rittman, B.E.; et al. Human gut microbiota in obesity and after gastric bypass. Proc. Natl. Acad. Sci. USA 2009, 106, 2365–2370.

Mentella, M.C.; Scaldaferri, F.; Pizzoferrato, M.; Gasbarrini, A.; Miggiano, G.A.D. Nutrition, IBD and gut microbiota: A review. Nutrients 2020, 12, 944.

Sommer, F.; Anderson, J.M.; Bharti, R.; Raes, J.; Rosentiel, P. The resilience of the intestinal microbiota influences health and disease. Nat. Rev. Microbiol. 2017, 15, 630–638.

Feng, Q.; Chen, W.D.; Wang, Y.D. Gut microbiota–an integral moderator in health and disease. Front. Microbiol. 2018, 9, 151.

Gao, Z.; Guo, B.; Gao, R.; Zhu, Q.; Qin, H. Microbiota disbiosis is associated with colorectal cancer. Front. Microbiol. 2015, 6, 20. [CrossRef]

Bautista-Ortín, A.B.; Cano-Lechuga, M.; Ruiz-García, Y.; Gómez-Plaza, E. Interactions between grape skin cell wall material and commercial enological tannins. Practical implications. Food Chem. 2014, 152, 558–565.

Liu, X.; Le Bourvellec, C.; Renard, C.M.G.C. Interactions between cell wall polysaccharides and polyphenols: Effect of molecular internal structure. Compr. Rev. Food Sci. Food Saf. 2020, 19, 3574–3617.

Hu, J.; Bi, J.; Li, X.; Wu, X.; Wang, W.; Yu, Q. Understanding the impact of pectin on browning of polyphenol oxidation system in thermal and storage processing. Carbohydr. Polym. 2023, 307, 120641.

Watrelot, A.A.; Le Bourvellec, C.; Imberty, A.; Renard, C.M.G.C. Interactions between pectic compounds and procyanidins are influenced by methylation degree and chain length. Biomacromolecules 2013, 14, 709–718.

Fernandes, P.A.R.; Le Bourvellec, C.; Renard, C.M.G.C.; Wessel, D.F.; Cardoso, S.M.; Coimbra, M.A. Interactions of arabinan-rich pectic polysaccharides with polyphenols. Carbohydr. Polym. 2020, 230, 115644.

Le Bourvellec, C.; Guyot, S.; Renard, C.M.G.C. Interactions between apple (Malus x domestica Borkh.) polyphenols and cell walls modulate the extractability of polysaccharides. Carbohydr. Polym. 2009, 75, 251–261.

Domínguez-Rodríguez, G.; Marina, M.L.; Plaza, M. Strategies for the extraction and analysis of non-extractable polyphenols from plants. J. Chromatogr. A 2017, 1514, 1–15.

Saura-Calixto, F.; Pérez-Jiménez, J.; Touriño, S.; Serrano, J.; Fuguet, E.; Torres, J.L.; Goñi, I. Proanthocyanidin metabolites associated with dietary fibre from in vitro colonic fermentation and proanthocyanidin metabolites in human plasma. Mol. Nutr. Food Res. 2010, 54, 939–946.

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Published

2025-03-04

How to Cite

Hawraa Ridha Jubair, Farah Kazim Abbas, & Baneen Hussein Ali, Haidar Muhammad Akool, Tabarek Mohsin Dhahir. (2025). Nutritional Effects of Polyphenols, Dietary Fiber, Prebiotic effect, Compounds Associated with Dietary Fiber and Impact of Polyphenols on Human Intestinal Microbiota and Their Health Benefits . Current Clinical and Medical Education, 3(03), 24–38. Retrieved from https://www.visionpublisher.info/index.php/ccme/article/view/217

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