Antioxidant Potential (Peroxynitrite scavenging, Singlet oxygen scavenging, and Hypochlorous acid scavenging) and Anti-Inflammatory Effect of Apiumgraveolens and Investigation of Its Bioactive Natural Compound Using FTIR Analytical Technique
Keywords:
Peroxynitrite, Singlet oxygen, Hypochlorous acid scavenging, ApiumAbstract
The objective of our study is to conduct a chemical analysis of Apium
graveolens and to assess the anti-inflammatory and antioxidant capabilities of several
extracts, including methanol, ethyl acetate, ethanol, hexan, and water. To get ready for
FTIR analysis, a tiny quantity of powdered samples was dissolved in KBr and then
compressed into a thin film. A wave number range spanning from 4000 cm−1 to 500 cm
−1 was used to gather data on the transmittance of infrared light. The albino rats used in
the studies ranged in weight from 175 to 225 gram. The animal breeding house was the
source for the animals. The animals in group I were utilized as a control group and were
given maize oil as a vehicle. 100 mg/kg Di-(2- ethylhexyl) phthalate were the positive
controls in all trials involving Apium graveolens methanol fraction. Group 1 consisted of
Di-(2- ethylhexyl) phthalate at a concentration of 100 mg/kg, Groups 2, and 3 of
fractions of Apium graveolens at concentrations of 0.50 mL/kg, and 0.75 mL/kg,
respectively. Di(2-ethylhexyl)phthalate causes chronic hepatotoxicity in rats. Hence, we
find that taking di(2-ethylhexyl) phthalate orally (1000 mg/kg body weight/day) as
laboratory tested for 4 weeks in rats resulted in a noticeable and significant increase in
the levels of serum enzymes such as (SGOT), (SGPT), and (ALP). Hence, we found that
taking A. graveolens seed extract (250 mg/kg.w./day) for 4 weeks leads to a significant
and significant recovery of these biochemical parameters towards the normal stable state
compared to di(2-ethylhexyl) phthalate-treated rats and their control. The results of this
study lend credence to the traditional medicinal usage of Apium graveolens, which has
been found to have anti-inflammatory and antioxidant properties.
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