Physiological study of liver and kidney of female patient with breast cancer which treated with different doses of Chemotherapy
Keywords:
breast cancer, Adriamycin, cyclophosphamide, liver enzyme, urea, creatinineAbstract
Following the evaluation of tumor histology, organ function is a crucial element to consider when selecting a chemotherapy regimen. Patients undergoing chemotherapy require a comprehensive evaluation of their liver function prior to treatment to determine which medications may not be acceptable and which drug doses should be adjusted. The common protocol in treatment of breast cancer is given mix anticancer drug cyclophosphamide and Adriamycin. It is crucial to understand that anomalies in liver function tests after therapy could be caused by the medication rather than the advancing illness. This page discusses the hepatic toxicity of chemotherapy drugs and offers dose adjustments in response to abnormalities in liver function. The focus is on substances that are recognized to be hepatotoxic, as well as those that have hepatic metabolism and renal failure . In this study taking 150 female patient with breast cancer and 30 healthy women. the 150 female patient divided in to three group depend on the number of chemotherapy dose taking during the treatment and making the following : first taking from one dose to four dose of chemotherapy , second taking from five dose to eight dose of chemotherapy , third taking from nine dose to above dose of chemotherapy may be reach twenty four dose . the result showed significant difference in liver enzyme AST,ALP and ALT . AST , ALT and ALP assessment showed significant decreased in all groups when compared with control group and showed significant increased of urea and creatinine when compared with control group. The different number of chemotherapy dose lead to disturbance of liver enzyme , urea and creatinine , and the side effect increased with increased number of dose .
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