Fluctuation of Thyroid Stimulating Hormone(TSH) During Pregnancy
Keywords:
TSH, T3, Fluctuation, PregnancyAbstract
Pregnancy causes a decrease in the upper and lower limits of maternal TSH levels compared to the typical reference range for non-pregnant TSH levels. This changes in the thyroid gland's physiology and common complications in pregnancy with serious consequences for the mother and adverse maternal outcome associated with abnormal maternal thyroid function. utilizing population-based trimester reference intervals (RIs) for thyroid testing is one of the recommendations suggested by international standards. This study aims to identify an optimal RI for thyroid-stimulating hormone (TSH) in pregnant Iraqi women.
Methods: A total of 80 women visiting primary health care centers in Babylon province aged 19 to 35 years (20 non pregnant women, 20 pregnant women in first trimesters: T1 (1-12 weeks), 20 pregnant women in second trimesters:T2 (13-25 weeks), and 20 pregnant women in third trimesters:T3(26-41 weeks) were used in the study. Women from Babil Governorate's primary health care centers participated in a reference interval study after exception certain medical and prenatal history criteria.
Results: The results upper limits of the TSH reference range of pregnant groups were all lower than that of non pregnant group reference of upper limits. The results of TSH reference range was 0.42 to 1.94 mIU/L, 0.30 to 1.71 mIU/L, 0.12 to 3.00 mIU/L in the first, second and third trimesters respectively. Also in the second trimester there was lowest level of the upper limit for TSH and T3 whereas in the third trimester was the lowest value of the lower limit for TSH and T3.
Conclusions: To diagnose thyroid conditions during pregnancy it is necessary to establish pregnancy-specific and laboratory RIs, especially for TSH. during pregnancy, the function of the thyroid gland changes in women, especially TSH and free T3.
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